Connoisseurs have no qualms about building an entire vacation around wine. Whether you’re heading to Napa Valley, Tuscany, or an emerging wine region, you can find chic hotels and exquisite private villas that offer intimate access to top producers. Explore how wine is made on guided tours, and then relax with a grape-based spa treatment or a gourmet meal at a Michelin-starred restaurant. Whatever your preferred terroir, Travel + Leisure advises on the best vineyards, tasting rooms, winery hotels, and itineraries.